To date, more than 400 different genes have been implicated in the causes of obesity or being overweight, although only a handful of these appear to be major players. 迄今为止，（研究者们发现）有超过400种不同的基因与超重或肥胖的原因有关，但是只有少数基因似乎是主要因素。 Genes contribute to the causes of obesity in many ways, by affecting appetite, satiety (the feeling of fullness), metabolism, body-fat distribution, and the tendency to use eating as a way to cope with stress. 基因可以多方面影响肥胖的成因，它会影响食欲、饱腹感、新陈代谢、体脂分布、以及将饮食作为减压方式的倾向。 One or both of your parents or several other blood relatives are significantly overweight. If both of your parents have obesity, your likelihood of developing obesity is as high as 80%. 父母一方或双方，或者其他血亲有严重肥胖。如果你的父母都患有肥胖症，那么你的患肥胖的几率可能高达80%。 You can't lose weight even when you increase your physical activity and stick to a low-calories diet for many months. 就算多动并且减少热量摄入持续数个月体重也不会减少。